Virus cyst ovaries

The blood supply to the ovaries comes directly from the ovarian artery, a direct branch of the aorta. The venous drainage is unique as the right ovarian vein drains directly into the inferior vena cava, whereas the left renal vein drains the left ovarian vein.

In premenopausal women, the ovaries function to produce numerous follicles a month, with one dominant follicle maturing and undergoing ovulation. As a result of ovulation, a fluid-filled sac known as an ovarian cyst can form on one or both ovaries.

While SARS-CoV-2 has four main structural proteins, the spike protein S which is located at the outer surface of the virus particles and can bind to ACE2 on the cell surface and causes receptor-mediated endocytosis of the virus, is the main target to evoke the self-immune system.

The mRNA vaccines represent the newest generation of vaccines in which all components can be engineered via chemical synthesis. An additional advantage of the mRNA vaccine is that the antigen expression generated by the mRNA is a transient process and therefore the risk of host DNA integration is negligible.

Furthermore, elimination of live materials poses an advantage from a quality control standpoint and allows quick product switching in manufacturing facilities. Since the process is fully-synthetic it also eliminates the risk of disease transmissions from the manufacturing facility.

The effect of the systemic generation and introduction of just the S protein of the SARS-CoV-2 could have a negative influence on ovarian follicles and oocytes has not been studied yet. Anti Mullarian Hormone AMH is a glycoprotein produced by the granulosa cells of the antral follicles. Its circulating levels are associated with the fertility state of the ovary and in contrast to other hormones are not influenced by the state of the menstrual cycle.

Therefore, AMH levels are considered the measurement of choice for estimating ovarian reserve. As Israel is the first country to widely vaccinate its population using the mRNA vaccines and due to all the aforementioned, the aim of this study is to evaluate the influence of the mRNA vaccines on ovarian reserve estimated by the change in AMH before and three-month following vaccination.

This is a prospective study including females that are planning to be vaccinated in Israel. Women will be asked to sign an informed consent to participate in the study while visiting the ambulatory vaccinating clinics before being vaccinated. Medical information will be collected by the research team during this visit using computerized questionnaire.

A follow up visit will be scheduled at three months after the first vaccination. During this visit, blood samples will be collected for AMH levels and for anti Covid antibody levels Serology. Additionally, women will be asked to complete a second computerized questionnaire which focused on possible adverse effects following vaccinations and gynecological well-being at 3,6 and 12 months from recruitment.

Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Try the modernized ClinicalTrials. Learn more about the modernization effort. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

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Federal Government. Read our disclaimer for details. Last Update Posted : January 13, Study Description. Show detailed description. Women with pelvic inflammatory disease PID — an infection of the pelvic area generally resulting from gonorrhea or chlamydia — are more likely to develop infected ovarian cysts.

The bacteria from these sexually transmitted diseases travel from the cervix into the uterus and may cause cysts to form. These cysts are filled with bacteria that can lead to sepsis if they rupture.

Blood flow to the ovary is reduced or cut off when the weight of a cyst causes the ovary to turn over on itself one or more times called ovarian torsion.

If this happens, surgery is necessary to restore blood flow. While some ruptured ovarian cysts can cause little to no symptoms, others are more severe. Your healthcare team can help you create a management plan that makes the most sense for you. This type of cyst, called a corpus luteum, produces hormones that initially help sustain the pregnancy.

The cyst usually goes away by the second trimester. Ectopic pregnancy is when a fertilized egg implants in an area outside of the uterus. Usually this happens in the fallopian tubes, but on rare occasions, it implants on an ovary.

Endometriosis is a condition in which tissue that lines the uterus grows outside of it. When endometrial tissue forms on the ovaries, it can produce a type of cyst called an endometrioma.